USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: UBE2N_HUMAN USC-OGP 2-DE database:  UBE2N_HUMAN UBE2N_HUMAN General information about the entry View entry in simple text format Entry name UBE2N_HUMAN Primary accession number P61088 Secondary accession number(s) Q16781 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=2.3.2.23 {ECO:0000269|PubMed:20061386}; AltName: Full=Bendless-like ubiquitin-conjugating enzyme; AltName: Full=E2 ubiquitin-conjugating enzyme N; AltName: Full=Ubc13; AltName: Full=UbcH13; AltName: Full=Ubiquitin carrier protein N; AltName: Full=Ubiquitin-protein ligase N;. Gene name Name=UBE2N Synonyms=BLU Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0587: pI=5.36; Mw=14908 SPOT OGP-0588: pI=5.74; Mw=14796 Cross-references UniProtKB/Swiss-Prot P61088; UBE2N_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBE2N_HUMAN Primary accession number P61088 Secondary accession number(s) Q16781 Q53Y81 Sequence was last modified on  April 26, 2004 (version 1) Annotations were last modified on  March 15, 2017 (version 161) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=2.3.2.23 {ECO:0000269|PubMed:20061386}; AltName: Full=Bendless-like ubiquitin-conjugating enzyme; AltName: Full=E2 ubiquitin-conjugating enzyme N; AltName: Full=Ubc13; AltName: Full=UbcH13; AltName: Full=Ubiquitin carrier protein N; AltName: Full=Ubiquitin-protein ligase N; Gene name Name=UBE2N Synonyms=BLU Encoded on Name=UBE2N; Synonyms=BLU Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; DNA damage; DNA repair; Isopeptide bond; Nucleotide-binding; Nucleus; Reference proteome; Transferase; Ubl conjugation; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D83004; BAA11675.1; -; mRNA EMBL BT006873; AAP35519.1; -; mRNA EMBL BC000396; AAH00396.1; -; mRNA EMBL BC003365; AAH03365.1; -; mRNA EMBL BC108704; AAI08705.1; -; mRNA CCDS CCDS31875.1; -; . PIR JC4894; JC4894; . RefSeq NP_003339.1; NM_003348.3; . UniGene Hs.524630; -; . PDB 1J7D; X-ray; 1.85 A; B=1-152 PDB 2C2V; X-ray; 2.90 A; B/E/H/K=2-152 PDB 3HCT; X-ray; 2.10 A; B=1-152 PDB 3HCU; X-ray; 2.60 A; B/D=1-152 PDB 3VON; X-ray; 3.15 A; C/E/G/J/L/N/Q/S/U/X/Z/b/e/g/i/l/n/p=3-150 PDB 3W31; X-ray; 2.96 A; B=1-152 PDB 4DHI; X-ray; 1.80 A; D=1-152 PDB 4DHJ; X-ray; 2.35 A; C/G/K/N=1-152 PDB 4DHZ; X-ray; 3.11 A; F=1-152 PDB 4IP3; X-ray; 2.30 A; B=1-152 PDB 4NR3; X-ray; 1.80 A; B=2-150 PDB 4NRG; X-ray; 1.95 A; B=1-152 PDB 4NRI; X-ray; 2.30 A; B=3-150 PDB 4ONL; X-ray; 1.35 A; B=1-152 PDB 4ONM; X-ray; 1.35 A; B=1-152 PDB 4ONN; X-ray; 1.50 A; B=1-152 PDB 4ORH; X-ray; 4.80 A; B/F/J=1-152 PDB 4TKP; X-ray; 2.08 A; A=2-152 PDB 4WHV; X-ray; 8.30 A; B/E/H/K=1-152 PDB 5AIT; X-ray; 3.40 A; B/E=1-152 PDB 5AIU; X-ray; 2.21 A; B/E=1-152 PDB 5EYA; X-ray; 2.40 A; A/B=1-152 PDBsum 1J7D; -; . PDBsum 2C2V; -; . PDBsum 3HCT; -; . PDBsum 3HCU; -; . PDBsum 3VON; -; . PDBsum 3W31; -; . PDBsum 4DHI; -; . PDBsum 4DHJ; -; . PDBsum 4DHZ; -; . PDBsum 4IP3; -; . PDBsum 4NR3; -; . PDBsum 4NRG; -; . PDBsum 4NRI; -; . PDBsum 4ONL; -; . PDBsum 4ONM; -; . PDBsum 4ONN; -; . PDBsum 4ORH; -; . PDBsum 4TKP; -; . PDBsum 4WHV; -; . PDBsum 5AIT; -; . PDBsum 5AIU; -; . PDBsum 5EYA; -; . ProteinModelPortal P61088; -; . SMR P61088; -; . BioGrid 113182; 164; . DIP DIP-29829N; -; . IntAct P61088; 134; . MINT MINT-5001139; -; . STRING 9606.ENSP00000316176; -; . BindingDB P61088; -; . ChEMBL CHEMBL6089; -; . iPTMnet P61088; -; . PhosphoSitePlus P61088; -; . SwissPalm P61088; -; . BioMuta UBE2N; -; . DMDM 46577660; -; . OGP Q16781; -; . REPRODUCTION-2DPAGE IPI00003949; -; . EPD P61088; -; . PaxDb P61088; -; . PeptideAtlas P61088; -; . PRIDE P61088; -; . TopDownProteomics P61088; -; . DNASU 7334; -; . Ensembl ENST00000318066; ENSP00000316176; ENSG00000177889; . GeneID 7334; -; . KEGG hsa:7334; -; . CTD 7334; -; . DisGeNET 7334; -; . GeneCards UBE2N; -; . HGNC HGNC:12492; UBE2N; . HPA HPA044976; -; . MalaCards UBE2N; -; . MIM 603679; gene; . neXtProt NX_P61088; -; . OpenTargets ENSG00000177889; -; . PharmGKB PA37141; -; . eggNOG KOG0417; Eukaryota; . eggNOG COG5078; LUCA; . GeneTree ENSGT00540000070023; -; . HOGENOM HOG000233455; -; . HOVERGEN HBG063308; -; . InParanoid P61088; -; . KO K10580; -; . OMA IDKWSPA; -; . PhylomeDB P61088; -; . TreeFam TF101126; -; . BRENDA 2.3.2.B6; 2681; . Reactome R-HSA-1169408; ISG15 antiviral mechanism; . Reactome R-HSA-168638; NOD1/2 Signaling Pathway; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; . Reactome R-HSA-446652; Interleukin-1 signaling; . Reactome R-HSA-450302; activated TAK1 mediates p38 MAPK activation; . Reactome R-HSA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; . Reactome R-HSA-5693571; Nonhomologous End-Joining (NHEJ); . Reactome R-HSA-5693607; Processing of DNA double-strand break ends; . Reactome R-HSA-5696395; Formation of Incision Complex in GG-NER; . Reactome R-HSA-69473; G2/M DNA damage checkpoint; . Reactome R-HSA-8866654; E3 ubiquitin ligases ubiquitinate target proteins; . Reactome R-HSA-937039; IRAK1 recruits IKK complex; . Reactome R-HSA-937041; IKK complex recruitment mediated by RIP1; . Reactome R-HSA-975110; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; . Reactome R-HSA-975144; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . SignaLink P61088; -; . SIGNOR P61088; -; . UniPathway UPA00143; -; . ChiTaRS UBE2N; human; . EvolutionaryTrace P61088; -; . GeneWiki UBE2N; -; . GenomeRNAi 7334; -; . PRO PR:P61088; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000177889; -; . CleanEx HS_UBE2N; -; . ExpressionAtlas P61088; baseline and differential; . Genevisible P61088; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0001650; C:fibrillar center; IDA:HPA; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IDA:MGI; . GO GO:0031372; C:UBC13-MMS2 complex; IDA:HGNC; . GO GO:0035370; C:UBC13-UEV1A complex; IDA:UniProtKB; . GO GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0043130; F:ubiquitin binding; IDA:HGNC; . GO GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central; . GO GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central; . GO GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB; . GO GO:0000187; P:activation of MAPK activity; TAS:Reactome; . GO GO:0006464; P:cellular protein modification process; TAS:ProtInc; . GO GO:0000729; P:DNA double-strand break processing; IMP:HGNC; . GO GO:0000724; P:double-strand break repair via homologous recombination; IMP:HGNC; . GO GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:Reactome; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0070911; P:global genome nucleotide-excision repair; TAS:Reactome; . GO GO:0016574; P:histone ubiquitination; IMP:HGNC; . GO GO:0007254; P:JNK cascade; TAS:Reactome; . GO GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome; . GO GO:0045739; P:positive regulation of DNA repair; IMP:HGNC; . GO GO:0031058; P:positive regulation of histone modification; IMP:HGNC; . GO GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:HGNC; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB; . GO GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IMP:HGNC; . GO GO:0006301; P:postreplication repair; IMP:HGNC; . GO GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB; . GO GO:0016567; P:protein ubiquitination; IMP:HGNC; . GO GO:0006508; P:proteolysis; TAS:ProtInc; . GO GO:0006282; P:regulation of DNA repair; TAS:ProtInc; . GO GO:0033182; P:regulation of histone ubiquitination; IMP:HGNC; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB; . Gene3D 3.10.110.10; -; 1; . InterPro IPR000608; UBQ-conjugat_E2; . InterPro IPR023313; UBQ-conjugating_AS; . InterPro IPR016135; UBQ-conjugating_enzyme/RWD; . Pfam PF00179; UQ_con; 1; . SUPFAM SSF54495; SSF54495; 1; . PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1; . PROSITE PS50127; UBIQUITIN_CONJUGAT_2; 1; .

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